ERBB2

ERBB2
Dostupne strukture PDB Pretraga ortologa: PDBe RCSB Spisak PDB ID kodova 1MFG, 1MFL, 1MW4, 1N8Z, 1QR1, 1S78, 2A91, 2JWA, 2KS1, 2L4K, 3BE1, 3H3B, 3N85, 3PP0, 3RCD, 3MZW, 3WLW, 3WSQ, 4GFU, 4HRL, 4HRM, 4HRN, 2N2A
Identifikatori
Aliasi	ERBB2
Vanjski ID-jevi	OMIM: 164870 MGI: 95410 HomoloGene: 3273 GeneCards: ERBB2
EC broj	2.7.10.1
Lokacija gena (čovjek) Hrom. Hromosom 17 (čovjek)[1] Bend 17q12 Početak 39,687,914 bp[1] Kraj 39,730,426 bp[1]
Lokacija gena (miš) Hrom. Hromosom 11 (miš)[2] Bend 11 61.75 cM|11 D Početak 98,303,296 bp[2] Kraj 98,328,542 bp[2]
Obrazac RNK ekspresije Više referentnih podataka o ekspresiji
Ontologija gena Molekularna funkcija • ErbB-3 class receptor binding • aktivnost sa transferazom • nucleotide binding • protein kinase activity • protein dimerization activity • growth factor binding • RNA polymerase I core binding • kinase activity • protein C-terminus binding • GO:0001948, GO:0016582 vezivanje za proteine • vezivanje identičnih proteina • protein heterodimerization activity • transmembrane receptor protein tyrosine kinase activity • protein tyrosine kinase activity • protein phosphatase binding • ATP binding • transmembrane signaling receptor activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • Receptorska tirozin-kinaza Ćelijska komponenta • integral component of membrane • membrana • myelin sheath • receptor complex • ćelijska membrana • basolateral plasma membrane • apical plasma membrane • perinuklearno područje citoplazme • endosome membrane • GO:0016023 citoplazmatska vezikula • jedro • citoplazma • citosol • integral component of plasma membrane • basal plasma membrane Biološki proces • positive regulation of protein phosphorylation • peripheral nervous system development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of immature T cell proliferation in thymus • positive regulation of MAP kinase activity • Fosforilacija • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of epithelial cell proliferation • cellular response to growth factor stimulus • Zarastanje rana • oligodendrocyte differentiation • regulation of angiogenesis • positive regulation of translation • transcription, DNA-templated • nervous system development • MAPK cascade • protein phosphorylation • heart development • cell surface receptor signaling pathway • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • positive regulation of cell growth • regulation of microtubule-based process • neuromuscular junction development • regulation of ERK1 and ERK2 cascade • myelination • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • positive regulation of transcription by RNA polymerase I • Ćelijska proliferacija • positive regulation of transcription by RNA polymerase III • motor neuron axon guidance • enzyme linked receptor protein signaling pathway • GO:0072468 Transdukcija signala • positive regulation of cell adhesion • positive regulation of protein targeting to membrane • ERBB2 signaling pathway • phosphatidylinositol phosphate biosynthetic process • GO:1901313 positive regulation of gene expression • peptidyl-tyrosine phosphorylation • regulation of cell motility • cellular response to epidermal growth factor stimulus • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II • negative regulation of ERBB signaling pathway • positive regulation of protein kinase B signaling • negative regulation of signal transduction • Ćelijska diferencijacija • negative regulation of apoptotic process • positive regulation of ERK1 and ERK2 cascade • GO:0007243 intracellular signal transduction • positive regulation of cell population proliferation • neuron differentiation • positive regulation of MAPK cascade Izvori:Amigo / QuickGO
Ortolozi
Vrste	Čovjek	Miš
Entrez	2064	13866
Ensembl	ENSG00000141736	ENSMUSG00000062312
UniProt	P04626	P70424
RefSeq (mRNK)	NM_001005862 NM_001289936 NM_001289937 NM_001289938 NM_004448	NM_001003817 NM_010152
RefSeq (bjelančevina)	NP_001005862 NP_001276865 NP_001276866 NP_001276867 NP_004439 NP_001369711 NP_001369712 NP_001369713 NP_001369714 NP_001369715 NP_001369716 NP_001369717 NP_001369718 NP_001369719 NP_001369720 NP_001369721 NP_001369722 NP_001369723 NP_001369724 NP_001369725 NP_001369726 NP_001369727 NP_001369728 NP_001369729 NP_001369730 NP_001369731 NP_001369732 NP_001369733 NP_001369734 NP_001369735	NP_001003817
Lokacija (UCSC)	Chr 17: 39.69 – 39.73 Mb	Chr 11: 98.3 – 98.33 Mb
PubMed pretraga	[3]	[4]
Wikipodaci
Pogledaj/uredi – čovjek Pogledaj/uredi – miš

Receptor tirozin-protein kinaze erbB-2, znan i kao CD340 (klaster diferencijacije 340), proto-onkogene Neu, Erbb2 (glodarski) ili ERBB2 (ljudski), je protein koji je kod ljudi kodiran genom ERBB2. ERBB je skraćeno od eritroblastičnog onkogena B, gena izoliranog iz ptičjeg genoma. Često se naziva i HER2 (od receptor ljudskog epidermnog faktora rasta 2) ili HER2/neu.^[5][6][7]

HER2 je član ljudske porodice receptora za epidermni faktor rasta (HER / EGFR / ERBB). Pokazalo se da pojačavanje ili pretjerano eksprimiranje ovog onkogena ima važnu ulogu u razvoju i napredovanju određenih agresivnih vrsta karcinoma dojke. Posljednjih godina protein je postao važan biomarker i cilj terapije za približno 30% pacijenata sa karcinomom dojke.^[8]

Gen

ERBB2, poznati proto-onkogen, nalazi se na dugom kraku ljudskog hromosoma 17 (17q12).

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000141736 - Ensembl, maj 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000062312 - Ensembl, maj 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ "ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Pristupljeno 14. 6. 2016.
6. ^ "ERBB2". Genetics Home Reference. Pristupljeno 19. 6. 2016.
7. ^ Barh D, Gunduz M (22. 1. 2015). Noninvasive Molecular Markers in Gynecologic Cancers. CRC Press. str. 427. ISBN 9781466569393.
8. ^ Greška kod citiranja: Nevaljana oznaka <ref>; nije naveden tekst za reference s imenom pmid23320171